Avagacestat (BMS-708163)
- Product Name
- Avagacestat (BMS-708163)
- CAS No.
- 1146699-66-2
- Chemical Name
- Avagacestat (BMS-708163)
- Synonyms
- CS-262;BMS-708163;Avagacestat;BMS-708163, >=98%;BMS708163;BMS 708163;BMS-708163 (Avagacestat);Avagacestat (BMS-708163);BMS708163;BMS 708163;AVAGACESTAT;Avagacestat BMS-708163 BMS708163;(R)-2-(4-Chloro-N-(2-fluoro-4-(1,2,4-oxadiazol-3-yl)benzyl)-phenylsulfonamido)-5,5,5-trifluoro
- CBNumber
- CB32470907
- Molecular Formula
- C20H17ClF4N4O4S
- Formula Weight
- 520.89
- MOL File
- 1146699-66-2.mol
Avagacestat (BMS-708163) Property
- Density
- 1.488
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; ≥177.6 mg/mL in DMSO; ≥47.6 mg/mL in EtOH with ultrasonic
- form
- Powder
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 16711
- Product name
- Avagacestat
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 16711
- Product name
- Avagacestat
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- 16711
- Product name
- Avagacestat
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $341
- Updated
- 2024/03/01
- Product number
- 6363
- Product name
- Avagacestat
- Purity
- ≥98%(HPLC)
- Packaging
- 5
- Price
- $72
- Updated
- 2021/12/16
- Product number
- 6363
- Product name
- Avagacestat
- Purity
- ≥98%(HPLC)
- Packaging
- 25
- Price
- $278
- Updated
- 2021/12/16
Avagacestat (BMS-708163) Chemical Properties,Usage,Production
Uses
Avagacestat acts as a γ-secretase inhibitor allowing for treatment of ALzheimer’s disease. On addition it has seen uses targeting embryonic signaling pathways, which control stem cell and cellular development process in cancer therapy.
Definition
ChEBI: Avagacestat is an oxadiazole and a ring assembly.
Biological Activity
bms-708163 is a potent selective and orally bioavailable inhibitor of γ-secretase with ic50 value of 0.3nm [1].the cleavage of amyloid precusor protein app by γ-secretase causes the production of aβ40 and aβ42, which are cytotoxic and cause ad. in vitro assay shows bms-708163 inhibits the formation of aβ40 and aβ42 in h4-8sw cells. it also inhibits the human recombinant cyps in vitro with ic50 value of 20μm. notch receptor is another substrate of γ-secretase. the inhibition of notch signal pathway results in some side effects. it is shown that the activity of bms-708163 to inhibit notch is 190-fold weaker than to app. in female rats, oral administration of bms-708163 significantly reduces the production of aβ in plasma and brain at 10mg/kg and 100mg/kg. in addition, bms-708163 also reduces aβ in brain and csf in male beagle dogs [1].
target
γ-secretase
storage
Store at +4°C
References
[1] gillman kw, starrett je jr, parker mf, xie k, bronson jj, marcin lr, mcelhone ke, bergstrom cp, mate ra, williams r, meredith je jr, burton cr, barten dm, toyn jh, roberts sb, lentz ka, houston jg, zaczek r, albright cf, decicco cp, macor je, olson re. discovery and evaluation of bms-708163, a potent, selective and orally bioavailable γ-secretase inhibitor. acs med chem lett. 2010 mar 22;1(3):120-4.
Avagacestat (BMS-708163) Preparation Products And Raw materials
Raw materials
Preparation Products
Avagacestat (BMS-708163) Suppliers
- Tel
- +1 (866) 930-6790
- Fax
- +1 (866) 333-9607
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- United States
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- Country
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View Lastest Price from Avagacestat (BMS-708163) manufacturers
- Product
- Avagacestat 1146699-66-2
- Price
- US $200.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg/Month
- Release date
- 2022-11-27
- Product
- Avagacestat (BMS-708163) 1146699-66-2
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-10